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Aug 31, 2022

Non-steroidal anti-inflammatory drugs, or NSAIDs, are among the most widely used drugs worldwide, available in both prescription and over-the-counter forms, such as aspirin, ibuprofen, naproxen, and others. Most NSAIDs, with the exception of aspirin, work by inhibiting the activity of a family of enzymes called cyclooxygenases, which drive inflammatory processes. But because these inflammatory processes can be beneficial in some contexts and because the drugs often elicit off-target effects, there are some concerns about their use. 

In this Aliquot, I describe current recommendations and concerns surrounding NSAID use. 

  • 00:00:00 - Introduction
  • 00:02:58 - Daily aspirin use and cardiovascular disease risk (clip from Q&A #9)
  • 00:07:02 - The pros and cons of low-dose aspirin (clip from Q&A #30)
  • 00:11:43 - Aspirin use and metastatic cancer risk
  • 00:13:46 - Aspirin vs other NSAIDs
  • 00:15:20 - Effects of ibuprofen on the kidneys, stomach, and muscles (clip from Q&A #14)
  • 00:18:52 - NSAIDs, heart attack, and stroke
  • 00:20:04 - Alternatives to NSAIDs

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